Asthma Treatment Rationale:What cohort size was the tested group?

Remember – Critical discussion of the evidence is essential – simply stating what the guidelines or research trial said is not enough!
You should instead demonstrate your ability to evaluate the research methodology. Issues to consider may include:
o

Remember – Critical discussion of the evidence is essential – simply stating what the guidelines or research trial said is not enough!

You should instead demonstrate your ability  to evaluate the research methodology. Issues to consider may include:

  • What cohort size was the tested group?
  • Who was the medication tested on and can this be related to your patient – was the sample of a similar age, have similar disease characteristics, same ethnic background, etc.?
  • Was the trial conducted using a therapeutic dose?
  • Also consider any possible bias evident e.g. sponsorship by drug companies
  • If using local and/or national guidelines consider the extent to which they are current, are they supported by reliable evidence? Is there more recent research evidence that supports/does not support the guidelines?

Please comment on the impact of such issues on the reliability and validity of the research studies.

o Who was the medication tested on and can this be related to your patient – was the sample of a similar age, have similar disease characteristics, same ethnic background, etc.
o Was the trial conducted using a therapeutic dose?
o Also consider any possible bias evident e.g. sponsorship by drug companies
o If using local and/or national guidelines consider the extent to which they are current, are they supported by reliable evidence? Is there more recent research evidence that supports/does not support the guidelines?
Please comment on the impact of such issues on the reliability and validity of the research studies.

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