What reason might there be for the decrease in the enthalpic favorability of folding following cross-link formation? Is there a way that you can envision to test this hypothesis?
1) Why were different cross-linking chemistries examined? Is there a clear advantage to one strategy over another? 2) What are the considerations for the synthesis of each version of the cross-linked peptides? Does one sort of chemistry appear to be more applicable in complex biological environments? 3) What reason might there be for the decrease […]